Protein tyrosine kinase

Details Protein tyrosine kinase Protein tyrosine kinase

1995-05-19

1998-02-10

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

530350, 530326, 530328, 530329, C12N 912, C07K 700, C07K 1447

Patent

active

057168180

ABSTRACT:
The present invention is directed to a novel protein tyrosine kinase comprising a polypeptide having multiple protein kinase catalytic domains and, more particularly, two kinase catalytic domains and to genetic sequences encoding same. Two such kinases are described and designated JAK1 and JAK2.

REFERENCES:
Hanks et al. (1988) Science 2451: 42-52.
Firmbach-Kraft et al. (1990) Oncogene 5: 1329-1336.
Bernards (1991) Oncogene 6: 1185-1189.
Harpur et al. (1992). Oncogene 7: 1347-1353.
Wilks (1989) Proc. Natl. Acad. Sci. 86: 1603-1607.

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