Protein-TRAF6

Details Protein-TRAF6 Protein-TRAF6

1997-11-20

1998-06-16

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 71, 435 72, 436501, C07K 14705

Patent

active

057672440

ABSTRACT:
The invention provides methods and compositions relating to a novel tumor necrosis factor receptor associated factor number six (TRAF6) protein, which transcriptionally activates Nuclear Factor .kappa.B. The invention provides isolated TRAF6 hybridization probes and primers capable of hybridizing with the disclosed TRAF6 gene, nucleic acids encoding the subject TRAF6 proteins, methods of making the subject TRAF6 proteins, and methods of using the subject compositions in diagnosis and drug screening.

REFERENCES:
patent: 5710013 (1998-01-01), Goeddel et al.
Rothe et al. "TRAF2-mediated activation of NF-kappaB by TNF receptor 2 and CD40". Science 269:1424-1429, Sep. 1995.

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