Protein specific for cardiac and skeletal muscle

Details Protein specific for cardiac and skeletal muscle Protein specific for cardiac and skeletal muscle

2006-07-11

2006-07-11

Saidha, Tekchand (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S252300, C435S252320, C435S320100, C530S350000

Reexamination Certificate

active

07074908

ABSTRACT:
The present invention relates to a muscle-specific protein, Ozz, and nucleic acids encoding the protein, that regulates development and function of muscle cells. The invention further relates to muscle-specific regulated expression of the protein, and of heterologous genes under control of the same regulatory sequences. In a specific example, a murine Ozz protein of 285 amino acids is preferentially expressed by a 1.0 kb mRNA in heart and skeletal muscle. This protein shares significant homology with neuralized proteins, and associates with a number of muscle proteins, including β-catenin.

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NCBI GenBank Accession: Q9D0S4 GI:33301416 Definition: Neuralized-like protein 2; 285 aa DBSource: swissprot: locus NRL2—MOUSE, accession Q0D0S4; created: Sep. 15, 2003; sequence updated: Sep. 15, 2003; annotation updated: Sep. 15, 2003.
NCBI GenBank Accession: AK004524 GI:12835749 Definition: Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1190009E12 product:hypothetical SOCS domain, C-terminus of STAT-inhibitors containing protein, full insert sequence 1014 bp mRNA linear HTC Sep. 20, 2003.
NCBI GenBank Accession: AL591495 GI:20330140 Definition: Mouse DNA sequence from clone RP23-61O3 on chromosome 2, complete sequence 239758 bp DNA linear ROD Apr. 25, 2002.
NCBI GenBank Accession: NM—080749 GI:18152786 Definition:Homo sapienschromosome 20 open reading frame 163 (C20orf163), mRNA 1269 bp mRNA linear PRI Oct. 5, 2003.
NCBI GenBank Accession: XM—230848 GI:34860696 Definition:Rattus norvegicussimilar to chromosome 20 open reading frame 163; neuralized-like 2 (LOC311633), mRNA 988 bp mRNA linear ROD Oct. 23, 2003.

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