Protein S polypeptides and anti-peptide antibodies that inhibit

Details Protein S polypeptides and anti-peptide antibodies that inhibit Protein S polypeptides and anti-peptide antibodies that inhibit

1992-07-01

1994-06-14

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530325, 530327, 530328, 530329, 530830, 436501, 435 793, C07K 700, C07K 706, C07K 708, C07K 710

Patent

active

053211235

ABSTRACT:
The invention describes protein S polypeptides and anti-PS antibodies capable of inhibiting the binding of proteins to C4BP. The peptides and antibodies are useful in diagnostic methods and systems for purifying or detecting free protein S. In addition, the polypeptides are useful in therapeutic methods as an anti-coagulant.

REFERENCES:
patent: 4361509 (1982-11-01), Zimmerman et al.
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Malm, et al., "Inhibition of Human Vitamin-K-Dependent Protein -S-Cofactor Activity by a Monoclonal Antibody Specific for a Ca.sup.2+ -Dependent Epitope", in Eur. J. Biochem., 165:39-45 (1987).
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Schwartz, et al., "Plasma Protein S Deficiency in Familial Thrombotic Disease", Blood, 64: 1297-1300 (1984).

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