Protein S deletion variants deficient in C4BP binding activity b

Details Protein S deletion variants deficient in C4BP binding activity b Protein S deletion variants deficient in C4BP binding activity b

1995-05-05

1997-08-12

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 235, C12N 121, C12N 1563, C07H 2104

Patent

active

056564848

ABSTRACT:
The present invention relates to various functional variants of recombinant protein S (PS) that do not significantly bind C4b binding protein (C4BP) and uses of the variants as a therapeutic reagent. In particular the invention is directed at deletion mutants of protein S, having cofactor activity toward APC and lacking at least the two postulated C4BP binding domains of the SHBG-like domain of the corresponding mature wild type protein S. Such a deletion mutant in particular lacks at least amino acid residues 401-457 and 583-635 of the corresponding mature wild type human protein S.

REFERENCES:
patent: 5321123 (1994-06-01), Griffin et al.
patent: 5405946 (1995-04-01), Griffin et al.
Nelson, R., et al., "Binding of Protein S to C4b-binding Protein", The Journal of Biological Chemistry, vol. 267, No. 12, 1992, pp. 8140-8145.
Hong, J.C. et al. (1987) "Characterization and sequence analysis of a developmentally regulated putative cell wall protein gene isolated from soybean" J. Biol. Chem 262(17):8367-8376.
Chang, C.C. (1992) "Structure and function of human protein S" Diss. Abstr. Int'l. 54(02-C):528.
Chang, G.T.G. et al. (1991) "The carboxy terminal of human protein S is involved in the interaction with human C4b-binding protein" Blood 78(10, Suppl. 1):277a.
Gershagen, S. et al. (1991) "The genes for SHBG/ABP and the SHBG-like region of vitamin K-dependent protein S have evolved from a common ancestral gene" J. Ster. Biochem. Molec. Biol. 40(4-6):763-769.

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