Protein S deletion variants deficient in C4BP binding activity,

Details Protein S deletion variants deficient in C4BP binding activity, Protein S deletion variants deficient in C4BP binding activity,

1994-06-29

1997-09-02

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530380, A61K 3817, C07K 1447

Patent

active

056631421

ABSTRACT:
The present invention relates to various functional variants of recombinant protein S (PS) that do not significantly bind C4b binding protein (C4BP) and uses of the variants as a therapeutic reagent. In particular the invention is directed at deletion mutants of protein S, having cofactor activity toward APC and lacking at least the two postulated C4BP binding domains of the SHBG-like domain of the corresponding mature wild type protein S. Such a deletion mutant in particular lacks at least amino acid residues 401-457 and 583-635 of the corresponding mature wild type human protein S.

REFERENCES:
patent: 5321123 (1994-06-01), Griffin et al.
patent: 5405946 (1995-04-01), Griffin et al.
Chang, G.T.G. et al. (1991) "Characterization of thrombin-resistant variants of recombinant human protein S" Circulation 86(4):1-814.
Chang, G.T.G. et al. (1992) "The carboxy terminal loop of human protein S is involved in the interaction with human C4b-binding protein" Blood 78(10, Suppl. 1):277a.
By R. Nelson et al., "Binding of Protein S to C4b-binding Protein", The Journal of Biological Chemistry, 1992, vol. 267, No. 12, pp. 8140-8145.

Affiliated with

Also associated with

Rating

Protein S deletion variants deficient in C4BP binding activity, does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein S deletion variants deficient in C4BP binding activity, , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein S deletion variants deficient in C4BP binding activity, will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-308048