Protein Rim2

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S300000, C435S069700, C435S320100, C435S440000, C435S449000, C536S023500

Reexamination Certificate

active

06956104

ABSTRACT:
Provided is a protein used in the development of a therapeutic agent for neuron- or endocrine cell-related diseases, in which the transport system is involved. The protein has an amino acid sequence with one or more amino acids deleted, substituted, inserted or added relative to the amino acid sequence set forth under SEQ ID NO:1 in the Sequence Listing and which has a property to interact with GDP/GTP exchange factor II.

REFERENCES:
Rothman, J.E.,Mechanisms of Intracellular Protein Transport, Nature, 372, 55-63 (1994).
Südhof, T.C.,The Synaptic Vesicle Cycle: A Cycle of Protein-Protein Interactions, Nature, 375, 645-653 (1995).
Hawkins, R.D., et al.,Learning to Modulate Transmitter Release: Themes and Variations in Pynaptic Plasticity, Annu. Rev. Nuerosci., 16, 625-665 (1993).
Lonart, G., et al.,Mechanisms of Action of rab3A in Mossy Fiber LTP, Neuron, 21, 1141-1150 (1998).
Renström, E., et al.,Protein Kinase A-Dependent and Independent Stimulation of Exocytosis by cAMP in Mouse Pancreatic B-Cells, J. Physiology, 502.1, 105-118, (1997).
Yoshimura, K., et al.,Cyclic AMP Potentiates Substance P-Induced Amaylase Secretion by Augmenting the Effect of Calcium in the Rat Parotid Acinar Cells, Biochemica et Biophysica Acta, 1402, 171-187 (1998).
De Rooij, J., et al. ,Epac is a Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated by Cyclic AMP, Nature, 396, 474-477 (1998).
Kawasaki, H., et al.,A Family of cAMP-Binding Proteins that Directly Activate Rap1, Science, 282, 2275-2279 (1998).
Wang, Y., et al.,Rim is a Putative Rab3 Effector in Regulating Synaptic-Vesicle Fusion, Nature, 388, 593-598 (1997).
Mutagenesis of Cloned DNA, Current Protocols in Molecular Biology, vol. 1, Chapter 8, 8.0.1-8.5.10 (1997).
Expression Vectors, Catalog of Vectors, BIOS Scientific Publishers Ltd., 9-12 (1994).
Introduction of Plasmid DNA into Cells, Current Protocols in Molecular Biology, vol. 1, Unit 1.8, 1.8.1-1.8.10 (1997).
Introduction of DNA into Mammalian Cells, Current Protocols in Molecular Biology, vol. 1, Chapter 9, 9.0.1-9.8.2 (1997).
Transduction of Genes Using Retrovirus Vectors, Current Protocols in Molecular Biology, vol. 1, Unit 9.9, 9.9.1-9.17.3 (1996).
Immunology, Current Protocols in Molecular Biology, vol. 1, Chapter 11, 11.0.1-11.16.13 (1997).
Prentki, M. and Matschinsky, F.M.,Ca2+,cAMP, and Phaspholipid-Derived Messengers in Coupling Mechanisms of Insulin Secretion, Phys. Reviews, 67, 4, 1185-1248 (1987).
Shirataki, H., et al.,Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTB-Binding Protein Related to Synaptotagmin, Mol. Cell. Biol., 13, 4, 2061-2068 (1003).
Li, C., et al.,Synaptic Targeting of Rabphilin-3A, a Synaptic Vesicle Ca2+/Phospholipid-Binding Protein, Depends on rab3A/3C, Neuron, 13, 885-898 (1994).
Kotake, K., et al.,Noc2, a Putative Zinc Finger Protein Involved in Exocytosi in Endocrine Cells, J. Biol. Chem., 272, 47, 29407-29410 (1997).
Steinberg, R.A., et al.,Activation of Type 1 Cyclic AMP-Dependent Protein Kinases with Defective Cyclic AMP-Binding Sites, J. Biol. Chem., 262, 6, 2664-2671, (1987).
Tanaka, J., et al.,Cellular Distribution of the P2X, ATP, Receptor mRNA in the Brain and Non-Neuronal Organs of Rats, Arch. Histol. Cytol., 59, 485-490 (1996).
Jones, P.M. and Persaud, S.J.,Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic β-Cells, Endocrine Rev., vol. 19, 429-461 (1998).
Inagaki, N. et al.,Cloning and Functional Characterization of a Third Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Subtype Expressed in Insulin-Secreting Cells, Proc. Nat. Acad. Sci., 91, 2679-2683 (1994).
Gonoi, T. et al.,Functional Neuronal Ionotropic Glutamate Receptors are Expressed in the Non-Neuronal Cell Line MIN6, J. Biol. Chem., vol. 269, No. 25, 169898-169925, (1994).
Wang et al. “Rattus norvegicus RIM2mRNA, complete cds”, Database GenEmbl, Accession NO: AF199322, Jul. 4, 2000.
Wang et al. “RIM2”, Database SPTREMBL_16, Accession No: Q9J1S1, Oct. 1, 2000.
Wang, Y., et al.,Rim is a putative Rab3 effector in regulating synaptic-vesuicle fusion, Nature, vol. 388, 593-598 (1997).
Database Swall ‘Online!’, Andersson, B., et al.,Hypothetical 41.8 Kda Protein(Fragment), retrieved from EBI, Database accession No. 043413 (1998).
Database EMBL ‘Online!’, Ohara, O., et al.,Homo Sapiens mRNA for KIAA0751 protein, complete cds, retrieved from EBI, Accession No. AB018294 (1998).
Ozaki, N., et al.,cAMP-GEF11 is a direct target of cAMP in regulated exocytosis, Nature Cell Biology, vol. 2, 805-811 (2000).
Wang, Y., et al.,The RIM/NIM Family of Neuronal C2 Domain Proteins, JBC, vol. 275, No. 26, 20033-20044 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Protein Rim2 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein Rim2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein Rim2 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3451508

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.