Protein rib, a cell surface protein that confers immunity to man

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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530825, 4352534, 4242341, A61K 3909

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058690646

ABSTRACT:
This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.

REFERENCES:
patent: 4772584 (1988-09-01), Cleary et al.
patent: 5302386 (1994-04-01), Kasper et al.
patent: 5648241 (1997-07-01), Michel et al.
Baker et al., N. Engl. J. Med. 294:753-756 (1976).
Baker, J. Inf. Dis., 161:917-921 (1990).
Pritchard et al., Infect. Immun. 60:1598-1602 (1992).
Madoff et al, Infect. Immun., Jan, pp. 204-210, vol. 59(1), 1991.
Baker et al, J. Infect. Dis., Jul., vol. 154(1), pp. 47-54, 1986.
Baltimore, RS et al, J. of Immun, vol. 118(2), pp. 673-678, 1977.
Ferrieri, P, Reviews of Infect. Diseases, vol. 10, Supp. 2, Jul.-Aug., pp. S363-S366, 1988.
Michel, J.L. et al, Proc. Nat'l, Acad, Sci, USA, vol. 89, Nov., pp. 10060-10064, 1992.
Russell-Jones, G J et al, J. Exp. Med, Nov., vol. 160, pp. 1467-1475, 1984.
Salasia, S.I.O. et al, APMIS, vol. 102, pp. 925-930, 1994.
Wagner, A R et al, Infect. Immun, May, vol. 55(5), pp. 1170-1175, 1987.
Linden, ACTA path. microbiol. Immun. Scand. Sect. B, 91, pp. 145-151, 1983.
Lancefield, RC et al, J. of Exp. Med., vol. 142 pp. 165-179, 1975.
Mukasa, H. et al, Infect & Immun., vol. 7(4), pp. 578-585, 1973.
Flores, AE. et al, Zentralbl. Bakteriol. Mikrobiol, Hy8., vol.-259(2), pp. 165-178, Apr. 1985.
Lewin, Roger, Science, vol. 237, p. 1570, 1987.
Reeck et al, Cell, vol. 50, p. 667, Aug. 28, 1987.
Carberry-Goh et al, 1987, In:Streptococcal genetics, pp. 22-24.
Michel, James et al, pp. 214-218, In:Genetics and Molecular Biology of Streptococci, Lactococci, and Enterococci, 1991.
Coppel et al, In Methods in Molecular Biology, vol. 21, Antibody Screning of expression Libraries, pp. 277-296.

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