Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-06-06
2006-06-06
Carlson, Karen Cochrane (Department: 1653)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C530S350000
Reexamination Certificate
active
07056684
ABSTRACT:
The present invention relates to (a) the establishment of a direct consequence to the mitochondrial import of phosphorylated p66ShcAand its association with prohibitin, and (b) to a potential function for the prohibitin-p66ShcAcomplex in the mitochondrial membrane depolarization process that governs metabolic events such as bioenergetics and free radical formation. The present invention can also be employed as a tool for identifying pharmaceutically active compounds that disrupt the prohibitin-p66ShcAinteraction, thereby providing treatment options for aging-related diseases such as diabetes, cardiovascular, osteoporosis, cancer and neurodegenerative diseases.
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Bristol--Myers Squibb Company
Carlson Karen Cochrane
Lamerdin John A.
Wilk-Orescan Rosemarie R.
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