Combinatorial chemistry technology: method – library – apparatus – Library – per se – Library containing only organic compounds
Reexamination Certificate
2004-12-06
2010-02-16
Lundgren, Jeffrey S. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Library, per se
Library containing only organic compounds
C506S013000, C562S063000
Reexamination Certificate
active
07662750
ABSTRACT:
The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction. The method involves contacting interacting proteins of a protein-protein interaction target with a compound as described herein, whereby the protein-protein interaction between the interacting proteins is modulated.
REFERENCES:
Dixon et al., “Preparation of a series of substituted fluoromethylnaphthalenes” Canadian Journal of Chemistry 1981, 59(17), 2629-2641.
Buchi, J. “The Constitution-Effect Relationships from a New Viewpoint” Deutsche Apotheker-Zeitung 1966, pp. 1695-1700 (1-29 for English translation).
Hanauska et al, ‘In vitro and in vivo Predictive Tests.’ In: Cancer Medicine E.5, Edited by Bast et al. London: B.C. Decker Inc. , 2000, pp. 585-588.
Grier et al., “The Pathophysiology of HOX genes and their role in cancer” Journal of Pathology 2005, 205, pp. 154-171.
Zhao et al., “inhibiting protein-protein interactions using designed molecules” Current Opinion in Structural Biology 2005, 15, 31-34.
Lipinski, Annual Reports in Medicinal Chemistry, 21:283-291 (1986).
Patani et al., Chem. Rev., 96:3147-3176 (1996).
Knoepfler et al., Mol. Cell. Bio., 15(10):5811-5819 (1995).
Dixon et al., “Preparation of a Series of Substituted Fluoromethylnaphthalenes,” Canadian J. of Chemistry, 59:2629-41 (1981).
Ji et al., “Privileged Scaffolds for Blocking Protein-Protein Interactions: 1,4-Disubstitued Naphthalene Antagonists of Transcription Factor Complex HOX-PBX/DNA,”Bioorganic&Medicinal Chemistry Letters14:3875-3879 (2004).
Knoepfler et al., “The Pentapeptide Motif of Hox Proteins is Required for Cooperative DNA Binding with Pbx1, Physically Contacts Pbx1, and Enhances DNA Binding by Pbx1,”Molecular and Cellular Biology15(10):5811-5819 (1995).
Hangauer David G.
Ji Tao
Lee Madison
Pruitt Steven
Lundgren Jeffrey S.
Nixon & Peabody LLP
Roswell Park Cancer Institute
The Research Foundation of State University of New York
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