Protein possessing metastasis-inhibitory activity

Details Protein possessing metastasis-inhibitory activity Protein possessing metastasis-inhibitory activity

1993-09-27

1996-03-12

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

424577, 435227, 536 221, 536 231, 536 232, 536 235, C07K 100, C07K 200, C07H 1900, C07H 2100

Patent

active

054986974

ABSTRACT:
Disclosed is a novel protein which has a molecular weight of 45,000.+-.5,000 and pI 5.7.+-.0.5 and exhibits cancer metastasis-inhibitory activity. The protein can be prepared by culturing human cells, animal cells and microorganisms capable of producing the protein in a nutrient culture medium while stimulating them with an inducer such as Bacille Calmette-Guerin and lipopolysaccharide.

REFERENCES:
patent: 5126148 (1992-06-01), Kurimoto et al.
Jakob et al, Molecular Cloning and Sequence Analysis of DNA's . . . Aminoacylase, Biological Chemistry, vol. 372, p. 684, 1991.
Cook et al, Cloning, Sequence, and Expression Analysis of a Chromosome . . . Cancer, J. Biol. Chem., vol 268, pp. 17010-17017, 1993.
Y. Naomoto et al., Journal of Cancer Research and Clinical Oncology, vol. 113, (1987), pp. 544-549.
U. K. Laemmli, Nature, vol. 227, (1970), pp. 680-685.
J. Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, (1989), Chapter 8, "Construction and Analysis of cDNA Laboratories", pp. 8.2-8.86.
Miller et al., "Human Aminoacylase-1: Cloning, Regional Assignment to Distal Chromosome 3p21.1, and Identification of a Cross-Hybridizing Sequence on Chromosome 18," Genomics, vol. 8, pp. 149-154 (1990).

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