Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Scleroproteins – e.g. – fibroin – elastin – silk – etc.
Patent
1984-09-24
1986-09-30
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Scleroproteins, e.g., fibroin, elastin, silk, etc.
530353, 426656, 426657, 426658, C08H 100, C08H 106, A61L 2700
Patent
active
046147942
ABSTRACT:
Complexes of polyanionic plant polysaccharides with biodegradable proteins, or proteolytic degradation products thereof, are useful in the formation of wound dressings and surgical implants, such as sutures, blood vessel grafts, and artificial organs. The biodegradable protein is preferably collagen, and the polysaccharide is preferably sodium alginate. The complexes are preferably formed by combining the protein and the polysaccharide at a pH which is no higher than the isoelectric point of the protein. The complexes may be crosslinked, such as by dehydrothermal crosslinking or by the use of chemical crosslinking agents such as aldehydes or carbodiimides. Multivalent cations may also be incorporated in the complex in order to give added strength.
REFERENCES:
patent: 3494772 (1970-02-01), Bradshaw et al.
patent: 3829587 (1974-08-01), Tolstoguzov et al.
patent: 4060081 (1977-11-01), Yannas et al.
Easton Ian A.
Gorham Stephen D.
Johnson & Johnson
Kight John
Nutter Nathan M.
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