Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1994-06-06
1998-08-11
Rories, Charles C.P.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 6, 435 691, 435 911, 435 913, 435 9131, 435 914, 4351723, 536 231, 536 245, 536 251, 536 253, 514 44, 530345, 530358, 530395, 530400, 530402, C12N 516, C12N 1587, C12Q 168, C07K 1706
Patent
active
057926450
ABSTRACT:
The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin-polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound to the transferrin receptor, which is highly regulated in growing cells, and absorbed into the cell. Suitable nucleic acids include those which inhibit specific genes or the RNA function, such as antisense oligonucleotides or ribozymes or the genes coding for them. The invention further relates to a process for introducing nucleic acids into the cells, transferrin-polycation
ucleic acid complexes and pharmaceutical preparations containing them.
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Beug Hartmut
Birnstiel Max L.
Cotten Matthew
Wagner Ernst
Boehringer Ingelheim International GmbH
Rories Charles C.P.
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