Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1990-03-09
1994-10-11
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530358, 530395, 530400, 530402, 536 231, 935 52, C07K 308, C07K 1506, C12N 1590
Patent
active
053548442
ABSTRACT:
The invention relates to a system for transporting nucleic acids into the cell, which is effected by receptor-mediated endocytosis. Using a transferrin-polycation conjugate, a complex can be formed with the polyanionic nucleic acid. This complex is bound to the transfertin receptor, which is highly regulated in growing cells, and absorbed into the cell. Suitable nucleic acids include those which inhibit specific genes or the RNA function, such as antisense oligonucleotides or ribozymes or the genes coding for them. The invention further relates to a process for introducing nucleic acids into the cells, transferrin-polycation
ucleic acid complexes and pharmaceutical preparations containing them.
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Beug Hartmut
Birnstiel Max L.
Cotten Matthew
Wagner Ernst
Boehringer Ingelheim International GmbH
Russel Jeffrey E.
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