Protein(poly)peptide libraries

Details Protein(poly)peptide libraries Protein(poly)peptide libraries

2007-09-04

2007-09-04

Zeman, Mary K. (Department: 1631)

Chemistry: molecular biology and microbiology

Vector, per se

C435S006120, C536S023100, C536S025300

Reexamination Certificate

active

09490064

ABSTRACT:
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.

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