Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-12-12
2000-07-25
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 231, 536 235, 536 232, 435 691, 435 692, 435440, 435196, 435 6, 435325, 4353201, C12N 121, C12N 1512, C12N 1563
Patent
active
060935650
ABSTRACT:
The present invention provides a human protein phosphatase regulatory subunit (HCNB) and polynucleotides which identify and encode HCNB. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HCNB and a method for producing HCNB. The invention also provides for agonists, antibodies, or antagonists specifically binding HCNB, and their use, in the prevention and treatment of diseases associated with expression of HCNB. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HCNB for the treatment of diseases associated with the expression of HCNB. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HCNB.
REFERENCES:
GenBank entry W63593, Nov. 1996.
Charbonneau, H., et al., "1002 Protein Phosphatases?," Annu. Rev. Cell Biol., 8:463-493 (1992).
Cohen, P., "The Structure and Regulation of Protein Phosphatases," Annu. Rev. Biochem., 58:453-508 (1989).
Aitken, A., et al., "The structure of the B subunit of calcineurin," Eur. J. Biochem., 139:663-671 (1984) (GI 461682).
Schwaninger, M., et al., "Inhibition of cAMP-responsive Element-mediated Gene Transcription by Cyclosporin A and FK506 after Membrane Depolarization," J. Biol. Chem., 268(31):23111-23115 (1993).
Mulkey, R.M., "An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression," Science, 261:1051-1055 (1993).
Remillard, S.P., et al., "A calcineurin-B-encoding gene expressed during differentiation of the amoeboflagellate Naegleria gruberi contains two introns," Gene, 154:39-45 (1995).
Ueki, K., et al., "Structure and Expression of Two Isoforms of the Murine Calmodulin-Dependent Protein Phosphatase Regulatory Subunit (Calcineurin B)," Biochem. Biophys. Res. Commun., 187(1):537-543 (1992).
Perrino, B.A., et al., "Characterization of the Phosphatase Activity of a Baculovirus-expressed Calcineurin A Isoform," J. Biol. Chem., 267(22):15965-15969 (1992).
Adams, M.D., et al., "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence," Nature, 377:1-17 (1995).
Hillier, L., et al., EMBL Sequence Database, Accession No. WO7658, XP002062995, Apr. 27, 1996.
Naik, U.P. et al., "Identification of a Novel Calcium-binding Protein That Interacts with the Integrin Glycoprotein IIb Cytoplasmic Domain," Circulation, vol. 9, No. 8 Supp., 1996, p. 1461.
Yuan, O., "Snk, a ser/thr protein kinase, associated proteins," EMBL Sequence Database entry, Accession No. U83236, XP002062998, Jan. 19, 1997.
Wu, X. et al., "A Novel Protein, KIP, Interacts with DNA-PK", EMBL Sequence Database entry, Accession No. U85611, XP002062999, Jun. 3, 1997.
GENBANK entry AA149750, Nov. 1996.
GENBANK entry N30277, Jan. 1996.
GENBANK entry H83672, Nov. 1995.
GENBANK entry U83236, Jan. 1997.
U.P. Naik et al. "Identification of a Novel Calcium Binding Protein That Interacts with the Integrin Alpha-IIb Cytoplasmic Domain", J. Biol. Chem. 272(8):4651-4654, Feb. 1997.
T.E. Creighton, "Proteins: Structures and Molecular Properties", W.H. Freeman and Company, New York 108-109, 132-133, 1984.
U.P. Naik et al. Identification of a Novel Calcium Binding Protein that Interacts with the Integrin Glycoprotein IIb Cytoplasmic Domain Circulation 94(8-Suppl): 461, Oct. 1996.
Goli Surya K.
Hillman Jennifer L.
Incyte Pharmaceuticals Inc.
Prouty Rebecca E.
LandOfFree
Protein phosphatase regulatory subunit does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein phosphatase regulatory subunit, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein phosphatase regulatory subunit will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1335593