Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-03-31
1996-08-13
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530350, 530399, A61K 3514, A61K 3818, A61K 3816, C07K 14475
Patent
active
055457207
ABSTRACT:
A protein named PHBP-70 having a wound-healing activity which has a molecular weight of about 60-80 KDa by analysis with SDS-PAGE under reducing conditions and can be obtained from the blood of the fetus and neonates of mammals including human beings. The protein PHBP-70 is a novel protein having a fibroblast proliferating activity and thus it is useful as a wound-healing agent.
REFERENCES:
patent: 5166317 (1992-11-01), Wallace et al.
patent: 5227302 (1993-07-01), Heldin et al.
Casscells et al. "Isolation, Characterization, & Localization of Heparin-Binding Growth Factors In The Head"J Clin Invest. 85 433-441 1990.
Marikovsky et al. "Appearance of Heparin-Binding EhF-life growth Factor In Wound Fluid as a Response To Injury" Proc Natl Acad Sci. go 3889-3893 1993 .
Doi Kazuyuki
Koyama Masayoshi
Takahashi Mikiko
Chan Christina Y.
Degen Nancy J.
Hoechst Japan Limited
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