Protein- or peptide-cochleate vaccines and methods of immunizing

Details Protein- or peptide-cochleate vaccines and methods of immunizing Protein- or peptide-cochleate vaccines and methods of immunizing

1993-10-04

1997-07-01

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424121, 264 46, 514 8, A61K 3900, A61K 5100, A61K 3816, B01J 1302

Patent

active

056435746

ABSTRACT:
A method is described of immunizing a host by administering a biologically effective amount of a protein- or peptide-cochleate comprising at least a protein or peptide to which an immune response is elicited, a negatively charged lipid, and a divalent cation.

REFERENCES:
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patent: 4663161 (1987-05-01), Mannino et al.
patent: 4871488 (1989-10-01), Mannino et al.
Miller et al, Vaccination of Rhesus Monkeys with Synthetic Peptide in a Fusogenic Proteoliposome Elicits Simian Immunodeficiency Virus-Specific CD8+ Cytotoxic T Lymphocytes, J. Exp. Med., vol. 176, pp. 1739-1744, 1992.
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