Protein O-sulfonation

Details Protein O-sulfonation Protein O-sulfonation

2006-11-09

2010-06-22

Ramirez, Delia M (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S015000, C435S023000

Reexamination Certificate

active

07741021

ABSTRACT:
Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions.Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

REFERENCES:
patent: 4444682 (1984-04-01), Rivier et al.
patent: 2006/0246531 (2006-11-01), Shokat et al.

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