Protein O-sulfonation

Details Protein O-sulfonation Protein O-sulfonation

2006-11-21

2006-11-21

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S015000, C435S019000, C435S070210, C435S007100

Reexamination Certificate

active

07138228

ABSTRACT:
Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.

REFERENCES:
Hiltz et al. PNAS 1955, 41, 880.
Bettelheim et al. JACS 1954, 76, 2838-2839.
Conboy et al. J. Am.SOc Mass Spect 1992, 3, 804-814.

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