Protein non-adsorptive polyurea-urethane polymer coated devices

Details Protein non-adsorptive polyurea-urethane polymer coated devices Protein non-adsorptive polyurea-urethane polymer coated devices

1991-03-06

1992-12-08

Kight, III, John

Stock material or miscellaneous articles

Composite

Of polyamidoester

528 48, 528 52, 528 53, 528 59, 528904, 427 2, 4272071, 427221, 427435, 21050024, 4284239, 4284242, 4284246, 4284251, 4284255, 4284256, 604 8, 604 19, 604403, B32B 2740

Patent

active

051697203

ABSTRACT:
Polymer-coated medical and laboratory devices are disclosed which are characterized by their biocompatibility and resistance to nonspecific protein adsorption. The polyurea-polyurethane coatings of this invention are prepared from high molecular weight isocyanate end-capped prepolymers substantially or exclusively comprised of ethylene oxide units. At least 75%, preferably at least 90%, of the prepolymer units are oxyethylene-based diols or polyols having molecular weights of about 7000-30,000, with essentially all of the hydroxyl groups capped with polyisocyanate prior to formation of the hydrated polymer coating.

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Coury et al., "Biomedical Uses of Polyurethanes"; Advances in Urethane Science and Technology; vol. 9, pp. 130-168 (1984).
Seifert et al., "Evaluation of In Vivo Adsorption of Blood Elements onto Hydrogel-Coated Silicone Rubber by Scanning Electron Microscopy and Fourier Transform Infrared Spectroscopy"; J. Biomed. Matls. Res., vol. 19, pp. 1043-1071 (1985).
Gregonis et al., "Poly(ethylene glycol) Surfaces to Minimize Protein Adsorption".

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