Protein nanomatrixes and method of production

Details Protein nanomatrixes and method of production Protein nanomatrixes and method of production

1992-10-13

1994-05-03

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424486, 424489, 424499, 2523151, A61K 914

Patent

active

053086201

ABSTRACT:
The present invention is a novel method of producing a unique device of stable porous and membraneless nanomatrixes for carrying medication for in vivo administration. The present invention method produces the device of stable nanomatrixes by mixing a first type of protein which is hemoglobin, a second type of protein which is albumin, and a solution containing an organic solvent which is an alcohol, where the weight ratio of the first and second type of proteins is within the range of approximately 92.+-.5 to 8.+-.5. This results in a turbid suspension of monodispersed nanomatrixes which are typically larger than 1 micron but less than 4 microns in diameter and stable against aggregation and re-solubilization in hypotonic saline for at least 24 hours. An additional solution containing a biologically active substance may be added before or after the solution containing an organic solvent, such that the biologically active substance is entrapped within or bound on the surfaces of the nanomatrixes.

REFERENCES:
patent: 4447355 (1984-05-01), Sakamoto et al.
patent: 5049322 (1991-09-01), De Vissaguet et al.
Remington's Pharma. Sci. 1985, p. 271.
Lehninger Biochemistry 1972, p. 134.

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