Protein molecules and uses therefor

Details Protein molecules and uses therefor Protein molecules and uses therefor

1998-06-04

2000-06-13

Carlson, Karen Cochrane

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins from animals other than mammals or birds

Snakes; venom

514 21, 514822, A61K 3800

Patent

active

060751290

ABSTRACT:
The present invention relates generally to protein molecules and to derivatives, homologues, analogues and mimetics thereof capable of inducing or facilitating inhibition of blood clot formation and more particularly platelet aggregation. The present invention also contemplates genetic sequences encoding said protein molecules and derivatives, homologues, analogues and mimetics thereof. The molecules of the present invention are useful inter alia in a range of therapeutic and prophylactic applications.

REFERENCES:
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4018653 (1977-04-01), Mennen
patent: 4424279 (1984-01-01), Bohn et al.
Takasaki et al. Amino acid sequences of eight phospholipases A2 from the venom of Australian King Brown Snake, Pseudechis australis, Toxicon 28(3): 329-339, 1990.
Kini & Evans. Effects of snake venom proteins on blood platelets. Toxicon 28(12): 1387-1422, 1990.
Kini & Evans. A model to explain the pharmacological effects of snake venom phospholipases A2. Toxicon 27(6): 613-635, 1989.
Chow et al., "Purification, Characterization, and Amino Acid Sequence Determination of Acanthins, Potent Inhibitors of Platelet Aggregation from Acanthophis antarcticus (Common Death Adder) Venom," Archives of Biochemistry and Biophysics, vol. 354, No. 2, pp. 232-238 (Jun. 15, 1988).

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