Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1985-01-18
1988-08-09
Wiseman, Thomas G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530403, 530406, 514 2, 514 76, 424 85, 424 88, 424450, 264 41, A61K 3900, A61K 942, A61J 500
Patent
active
047629150
ABSTRACT:
A lipid coupling reagent for use in coupling amine-containing molecules, such as proteins, to liposomes. The reagent includes phosphatidylethanolamine coupled to a 3-20 atom carbon-containing spacer arm terminating at a carboxyl or thiocarboxyl group. Also disclosed are liposomes prepared to include between about 1 and 20 mole percent of the coupling reagent, and liposomes containing surface arrays of proteins attached to the liposomes through the coupling reagent.
REFERENCES:
patent: 4485093 (1984-11-01), Runge
patent: 4486344 (1984-12-01), Buckler
Kinsky et al., J. Imm. Meth., vol. 65, pp. 295-306, 1983, "An Alternative Procedure for the Preparation of Immunogenic Liposomal Model Membranes".
Kinsky et al., Biochim. Biophys. Actu., vol. 769, p. 734, 1984.
Dancey et al., J. Immunology, vol. 122(2), Feb. 1979, "Immunogenicity of Liposomal Model Membranes Sensitized with Dinitrtophenylatedphosphatidylethanolamine Derivatives Containing Different Length Spacers".
Martin et al., J. Biol. Chem., vol. 257(1), Jun. 10, 1982, "Irreversible Coupling of Immunoglobulin Fragments to Preformed Vesicles", pp. 286-288.
Huang et al., Biochim. Biophys. Acta., vol. 716, 1982, pp. 140-150, "Characterization of Antibody Covalently Coupled to Liposomes".
Shen et al., Biochim. Biophys. Acta., vol. 689, 1988, pp. 31-37, "An Improved Method for Covalent Attachment of Antibody to Liposomes".
Kung Viola T.
Redemann Carl T.
Liposome Technology, Inc.
Teskin Robin Lyn
Wiseman Thomas G.
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