Protein lattice

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Details

C530S402000, C536S023100, C536S023400, C435S320100, C435S325000, C435S252300, C435S254110, C435S419000, C435S254200

Reexamination Certificate

active

07989591

ABSTRACT:
Protein lattices are disclosed which have a regular structure with a repeating unit repeating in three dimensions and have many uses, for example to support an array of macromolecular entities for X-ray crystallography. The repeating unit comprises protein protomers which each comprise at least two monomers fused together. The monomers are each monomers of a respective oligomer assembly into which the monomers are assembled for assembly of the protomers into the lattice. The repeating unit comprises protomers comprising at least a first monomer which is a monomer of a first oligomer assembly which has a set of rotational symmetry axes extending in three dimensions, and a further monomer fused to the first monomer which further monomer is a monomer of a further oligomer assembly which has a rotational symmetry axis of the same order as one of the set of rotational symmetry axes of the first oligomer assembly.

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