Protein labeling reagents

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530408, 424 11, C07K 1706, C07K 1528, A61K 4902, A61K 3944

Patent

active

051752565

ABSTRACT:
Novel labeling reagents are useful for radiolabeling proteins such as antibodies with radionuclide metals such as .sup.99m Tc, .sup.186 Re, and .sup.188 Re. The reagents are of the following formula: ##STR1## wherein: each X is independently chosen from O, S, NH, or NR.sub.2, wherein R.sub.2 is a protecting group or an electron withdrawing group;

REFERENCES:
patent: 2810753 (1957-10-01), Bersworth
patent: 3240799 (1966-03-01), Hageman et al.
patent: 3424740 (1969-01-01), Weaver et al.
patent: 3429871 (1969-02-01), Weaver et al.
patent: 3790568 (1974-02-01), Kerwood et al.
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4504462 (1985-03-01), Van Duzee et al.
patent: 4517123 (1985-05-01), Iso et al.
patent: 4659839 (1987-04-01), Nicolotti et al.
patent: 4709052 (1987-11-01), Tomioka et al.
patent: 4734498 (1988-03-01), Cooper
patent: 4883862 (1989-11-01), Chervu et al.
patent: 4897255 (1990-01-01), Fritzberg et al.
Green et al. (1981) in Protective Groups in Organic Synthesis John Wiley and Sons, NY, NY pp. 204-209 and 216-217.
Lever et al., Tetrahedron Letters, vol. 29, No. 26, pp. 3219-3222, 1988 (printed in Great Britain), "Synthesis of a novel bifunctional chelate designed for labeling proteins with technetium-99m".
Boyd et al., Int. J. Peptide Protein Res., 4, 1972, pp. 117-122, "N-acylsuccinimides as acylating agents for proteins: the selective acylation of lysine residues".
Medi-Physics, Inc. brochure for Product No. 4349, "MPI DMSA Kidney Reagent" Mar., 1989.
Blower et al., J. Nucl. Med., Abstract No. 253, published May 1990, vol. 31, No. 5, "Pentavalent rhenium-186 DMSA: A possible tumour therapy agent".
Kolasa and Miller, J. Org. Chem. 1986, 51, pp. 3055-3058, "A simple method for distinguishing optical isomers of chira amines, hydroxylamines, amino acids, and peptides".
Heterocyclic Compounds, vol. 45, pp. 145-147 and 186.
Pierce Chemical Company Immunotechnology Catalog and Handbook, pp. E-14 and E-15 (1990).
Wey et al., Abstracts of Papers, Part 2, from the 200th Amer. Chem. Soc. National Meeting, Aug. 26-31, 1990, Abstract No. 66.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Protein labeling reagents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein labeling reagents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein labeling reagents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1888166

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.