Protein label and drug delivery system

Details Protein label and drug delivery system Protein label and drug delivery system

1988-02-01

1989-12-26

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530390, 435181, 436532, C07D31182, G01N 33533, A61K 39395, C07K 1500

Patent

active

048899160

ABSTRACT:
A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manfacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically --SH groups.

REFERENCES:
patent: 4618492 (1986-10-01), Blattler et al.
Chemical Abstracts, vol. 100,pp. 430-431 (1984), Abstract No. 190020K.

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