Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-11-19
1988-06-14
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530390, 530391, 514 2, 25230116, 435181, 436 86, 436 88, 436532, A61K 3514, C12N 1106, G01N 3300
Patent
active
047512865
ABSTRACT:
A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manufacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically --SH groups.
REFERENCES:
patent: 3775378 (1973-11-01), Dahlmans et al.
patent: 4507234 (1985-03-01), Kato et al.
patent: 4543211 (1985-09-01), Kato et al.
patent: 4618492 (1986-10-01), Blattler et al.
Edidin Michael
Komoriya Akira
Packard Beverly
Nutter Nathan M.
Phillips Delbert R.
The Johns Hopkins University
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