Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-11-01
1991-10-08
Nutter, Nathan M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530402, 530810, 530811, 530812, 424 858, 424 8591, 436547, 436548, A61K 3514, C07K 300
Patent
active
050555618
ABSTRACT:
A bridging molecule carrying a drug, or a label such as a fluorophore, which adds across disulfide bonds of molecules, particularly proteins, and methods of manufacturing and using the bridging molecules, are disclosed. The bridging molecule is reactive with sulfhydryl groups formed by the reduction of disulfide bonds of the protein. The functional groups of the bridging molecules are typically --SH groups.
REFERENCES:
patent: 4698420 (1987-10-01), Urnovitz
Edidin Michael
Komoriya Akira
Packard Beverly
Nutter Nathan M.
The Johns Hopkins University
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