Protein L and subfragments thereof, with immunoglobulin binding

Details Protein L and subfragments thereof, with immunoglobulin binding Protein L and subfragments thereof, with immunoglobulin binding

1986-07-22

1989-10-24

Warden, Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

435243, 435259, 435262, 435267, 435803, 435810, 4352521, 514 2, 530350, 530412, 530413, 530825, C12P 2100

Patent

active

048761940

ABSTRACT:
This invention relates to a new protein L and subfragments thereof with binding activity for all classes of immunoglobulins from different species, a process for preparing the same, a reagent kit, a pharmaceutical composition and strain 312 of P. magnus. The process for preparing the protein and subfragments thereof is characterized in that the microorganism P. magnus 312 is treated with proteolytic enzymes or mutanolysin.

REFERENCES:
Biochemistry, Lehninger, 1978, Worth Pubs., pp. 157-173.
G. Kronvall and R. C. Williams, Jr., The Journal of Immunology, vol. 103, No. 4, Oct. 1969.
A. Forsgren and J. Sjoquist, The Journal of Immunology, vol. 97, No. 6, pp. 822-827.
J. J. Langone, Advances in Immunology, vol. 32, pp. 157-252, 1982.
M. Inganas, Scand. J. Immunol. 13, 343-352, 1981.
L. Bjorck and G. Kronvall, The Journal of Immunology, vol. 133, No. 2, Aug. 2, 1984.
E. B. Myhre and M. Erntell, Molecular Immunology, vol. 22, No. 8, pp. 879-885, 1985.
Bjorck; The Journal of Immunology; vol. 140, No. 4-2/15/88; A Novel Bacterial Cell Wall Protein with Affinity for Ig L Chains.sup.1.

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