Protein L and hybrid proteins thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 43525411, 4353201, 536 231, C12P 2102, C07H 2104, C12N 121, C12N 1563

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active

059653906

ABSTRACT:
The invention relates to sequences of protein L which bind to light chains of immunoglobulins. The invention also relates to hybrid proteins thereof which are able to bind to both light and heavy chains of immunoglobulin G, in particular protein LG. The invention also relates to DNA-sequences which code for the proteins, vectors which include such DNA-sequences, host cells which have been transformed with the vectors, methods for producing the proteins, reagent appliances for separation and identification of immunoglobulins, compositions and pharmaceutical compositions and pharmaceutical compositions which contain the proteins.

REFERENCES:
patent: 4876194 (1989-10-01), Bjorck et al.
patent: 5312901 (1994-05-01), Fahnestock
Kastern et al., "Structure of Peptostreptococcal Protein L and Identification of a Repeated Immunoglobulin Light Chain-binding Domain," Journal of Biological Chmistry 267(18):12820-12825, 1992.
Kastern et al., "Protein L, a Bacterial Immunoglobulin-Binding Protein and Possible Virulence Determinant," Infection and Immunity 58(5):1217-1222, 1990.
Bjorck, Lars, "Protein L, A Novel Bacterial Cell Wall Proetin with Affinity for Ig L Chains," Journal of Immunology 140(4):0000-0000, 1988.
Bjorck and Kronvall, "Purification and Some Properties of Streptococcal Protein G, a Novel IgG-Binding Reagent," Journal of Immunology 133(2), 969-974, 1984.
Sjobring et al., "Streptococcal Protein G Gene Structure and Protein Binding Properties," Journal of Biological Chemistry 266(1):399-405, 1991.
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Chateau et al., "On the Interaction between Protein L and Immunoglobulins of Various Mammalian Species," Scand. J. Immunol. 37:399-405, 1993.
Elbashir et al., "Antibody response in immunized rabbits measured with bacterial immunoglobulin-binding proteins," Journal of Immunological Methods 135:171-179, 1990.
Kihlberg et al., "Protein LG: A Hybrid Molecule with Unique Immunoglobulin Binding Properties," The Journal of Biological Chemistry 267(35):25583-25588, 1992.
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Lazar et al., "Transforming Growth Factor.alpha.: Mutation of Asparic Acid 47 and Leucine 48 Results in Different Biological Activities," Molecular and Cellular Biology 8(3):1247-1252, 1988.
Ng and Dillon, "Molecular fingerprinting of isolates and the genus Peptostreptococcus using rRNA genes from Escherichia coli and P. anaerobius," Journal of General Microbiology 137:1323-1331, 1991.
Nilson et al., "Protein L from Peptostreptococcus magnus Binds to the.kappa.Light Chain Variable Domain," The Journal of Biological Chemistry 267(4):2234-2239, 1992.
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