Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1997-01-17
1999-10-26
Weber, Jon P.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C12N 912
Patent
active
059726750
ABSTRACT:
The present invention describes a protein kinase which catalyzes the in phosphorylation of BRCA-1 protein. The present invention also describes the use of the BRCA-1 protein kinase as a molecular target for therapeutic intervention and/or as a therapeutic tool for diagnosing and treating breast and/or ovarian cancer.
REFERENCES:
Miki et al. (1994) Science, 266, "A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA-1", pp. 66-71.
Thomas et al. (1997) Cell Growth Differ., 8(7), "Induction of Phosphorylation on BRCA-1 During the Cell Cycle and after DNA Damage", pp. 801-809.
Chen et al. (1995) Science, 270, "Aberrant Subcellular Localization of BRCA1 in Breast Cancer", pp. 789-791.
Chen et al. (1996) Cancer Res., 56(14), "BRCA1 is a 220-kDA Nuclear Phosphoprotein That is Expressed and Phosphorylated in a Cell Cycle-Dependent Manner", pp. 3168-3172.
Jensen et al. (1996) Nature Gen., 12(3), "BRCA1 is Secreted and Exhibits Properties of a Granin", pp. 303-308.
Wang et al. (1997) Oncogene, 15(2), "BRCA1 Proteins are Transported to the Nucleus in the Absence of Serum and Splice Variants BRCA1a, BRCA1b are Tyrosine Phosphoproteins that Associate with E2F, Cyclins and Cyclin Dependent Kinases", pp. 143-157.
Wilson et al. (1996) Nature Gen., 13(3), "BRCA1 Protein Products: Antibody Specificity . . . ", pp. 264-265.
Koonin et al. (1996) Nature Gen., 13(3), ". . . Functional Motifs . . . ", pp. 266-268.
Diamandis (1996) Nature Gen., 13(3), ". . . and Secreted Tumor Suppressors", pp. 268.
Bradley et al. 1996) Nature Gen., 13(3), ". . . and Secreted Tumor Suppressors", pp. 268-269.
Jensen et al. (1996) Nature Gen., 13(3), ". . . and Secreted Tumor Suppressors", pp. 269-272.
Beckmann Richard P.
Burke Teresa F.
Cocke Kimberly S.
Lemke Stephanie J.
Boone David E.
Eli Lilly and Company
Gaylo Paul J.
Weber Jon P.
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