Protein kinase required for Ras signal transduction

Details Protein kinase required for Ras signal transduction Protein kinase required for Ras signal transduction

1995-12-13

1997-12-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 691, 4352523, 4353201, 530350, 536 231, 536 232, 536 235, C12N 912, C12P 2106, C07K 100, C07H 2104

Patent

active

057006750

ABSTRACT:
The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

REFERENCES:
Yao et al, 1995, Nature 378, 307-310; Phosphorylation of Raf by ceramide-activated protein kinase.
Dent et al., 1995, Science 268, 1902-1906; Reversal of Raf-1 Activation by Purified and Membrane-associated Protein Phosphatases.
Dent and Sturgill, 1994, PNAS USA 91, 9544-9548; Activation of (His)6-Raf-1 in vitro by partially purified plasma membranes from v-Ras-transformed and serum-stimulated fibroblasts.
Daum et al., 1994, TIBS 19, 474-480; The ins and outs of Raf kinases.
McCormick, 1994, TICB 4, 347-350; Raf: the Holy Grail of Ras Biology.
Downward et al. (1995). Cell 83: 831-834, Dec. 15, 1995.

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