Protein kinase required for Ras signal transduction

Details Protein kinase required for Ras signal transduction Protein kinase required for Ras signal transduction

1997-06-12

1998-05-05

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 4353201, 435194, 536 235, 530350, C12P 2106, C12N 120, C12N 1500, C07H 2104

Patent

active

057472882

ABSTRACT:
The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.

REFERENCES:
Downward et al. Cell. 83 :831-834, Dec. 15, 1995.

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