Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1997-08-12
1998-05-05
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435 691, 4352523, 4353201, 530350, 536 231, 536 235, C12Q 148, C12P 2106, C07K 100, C07H 2104
Patent
active
057472750
ABSTRACT:
The kinase suppressor of Ras (Ksr), a novel protein kinase involved in the regulation of cell growth and differentiation, provides an important target for therapeutic intervention. The subject compositions also include nucleic acids which encode a Ksr kinase, and hybridization probes and primers capable of hybridizing with a Ksr gene. Such probes are used to identify mutant Ksr alleles associated with disease. The invention includes methods, including phosphorylation and binding assays, for screening chemical libraries for lead compounds for a pharmacological agent useful in the diagnosis or treatment of disease associated Ksr activity or Ksr-dependent signal transduction.
REFERENCES:
Downward et al. (1995). Cell 83:831-834, 1995.
Chang Henry
Karim Felix
Rubin Gerry
Therrien Marc
Wassarman David
Osman Richard Aron
Saidha Tekchand
The Regents of the University of California
Wax Robert A.
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