Protein kinase inhibitors for treatmen of neurological disorders

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514450, 514211, 548418, A61K 3155

Patent

active

057418080

ABSTRACT:
The invention features novel derivatives of K-252a, as well as novel bis-N-substituted derivatives of staurosporine. The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a.

REFERENCES:
patent: 4554402 (1985-11-01), Hawkins et al.
patent: 4735939 (1988-04-01), McCoy et al.
patent: 4816450 (1989-03-01), Bell et al.
patent: 4877776 (1989-10-01), Murakata et al.
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5043335 (1991-08-01), Kleinschroth et al.
patent: 5093330 (1992-03-01), Caravatti et al.
patent: 5344926 (1994-09-01), Murakata et al.
patent: 5461146 (1995-10-01), Lewis et al.
patent: 5516771 (1996-05-01), Dionne et al.
Abe et al., "Arachidonic Acid Metabolism in Ischemic Neuronal Damage," Annals of the New York Academy of Sciences 559:259-268 (1989).
Borasio, "Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons," Neuroscience Letters 108:207-212 (1990).
Bozyczko-Coyne et al., "A rapid fluorometric assay to measure neuronal survival in vivo," Journal of Neuroscience Methods 50:205-216 (1993).
Chiu, A. et al., "A Motor Neuron-Specific Epitope and the Low Affinity Nerve Growth Factor Receptor Display . . . Development, Axotomy, and Regeneration," Journal of Comparative Neurology 328:328-363 (1993).
Davis et al., "Inhibitors of Protein Kinase C.1.sup.1 2,3-Bisarylmaleimides," J. Med. Chem. 35:177-184, 1992.
Davis et al., "Potent Selective Inhibitors of Protein Kinase C," FEBS Letters 259:61-63 (1989).
Dunnett, S. et al., "The basal forebrain--cortical cholinergic system: interpreting the functional consequences of excitotixic lesions," TINS 14:494-501 (1991).
Fibiger, H., "Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence," TINS 14:220-223 (1991).
Glicksman, M. et al., "K-252a and Staurosporine Promote Choline Acetyltransferase Activity in Rat Spinal Cord Cultures," Journal of Neurochemistry 61:210-221 (1993).
Glicksman, M., "K-252a Molecules as Promoters . . . ", Third Int. Conference on Nerve Growth Factor (NGF) and related molecule, Chateau Lake Louise, Lake Louise, Alberta, Apr. 26 -May 1, 1994.
Glicksman, M. et al., "K-252a Promotes Survival of Striatal Neurons in Culture," Society of Neuroscience Abstracts 19:680 (1993).
Hamburger, "Cell Death in the Development of the Lateral Motor Column of the Chick Embryo," J. Comp. Neur 160:535-546 (1975).
Hara et al., "Staurosporine, a Novel Protein Kinase C Inhibitor, Prevents Postischemic Neuronal Damage in the Gerbil and Rat," Journal of Cerebral Blood Flow and Metabolism 10:646-653 (1990).
Hashimoto et al., "Staurosporine-induced Neurite Outgrowth in PC12h Cells," Experimental Cell Research 184:351-359 (1989).
Hashimoto, "K-252a, a Potent Protein Kinase Inhibitor, Blocks Nerve Growth Factor-induced Neurite Outgrowth and Changes in the Phosphorylation of Proteins in PG12h Cells," J. Cell Biology 107:1531-1539.
Kase et al., "K-252a, A Protein Inhibitor of Protein Kinase C From Microbial Origin," The Journal of Antibiotics 39:1059-1065 (1986).
Kiyoto et al., "Staurosporine, a Potent Protein Kinase . . . Caused Ornithine Decarboxylase Induction in Isolated Mouse Epidermal Cells," Biochem. and Biophys. Research Communications 148:740-746 (1987).
Knusel et al., "K252b Selectively Potentiates Cellular Actions and trk Tyrasine Phosphorylation Mediated by Neuratrophin-3", Journal of Neurochemistry 59:715-722 (1992).
Knusel et al., "K-252b Is a Selective and Nontoxic Inhibitor of Nerve Growth Factor Action on Cultured Brain Neurons," Journal of Neurochemistry 57:995-961 (1991).
Koizumi et al., "K-252a: A Specific Inhibitor of the Action of Nerve Growth Factor on PC12 Cells," The Journal of Neuroscience B:715-721 (1988).
Lazarovici et al., "K-252a Inhibits the Increase in c-fos transcription and the Increase in Intracellular Calcium Produced by Nerve Growth Factor in PC12 Cells," Journal of Neuroscience Research 23:1-8 (1989).
McManamann, J. et al., "Reseue of Motoneurons from Cell Death by a Purified Skeletal Muscle Polypeptide: Effects of the Chat Development Factor, CDF," Neuron 4:891-898 (1990).
Matsuda et al., "The Effect of K-252a, A Potent Microbial Inhibitor of Protein Kinase, on Activated Cyclic Nucleotide Phosphodiesterase," Biochem J. 256:75-80 (1988).
Moody et al., "Synthesis of the Staurosporine Aglycon", J. Org. Chem. 57:2105-2114 (1992).
Morioka et al., "Staurosporine-Induced Differentiation in a Human Neuroblastoma Cell Line, NB-1," Agric. Biol. Chem. 49:1959-1963 (1985).
Nabeshima et al., "Staurosporine, a protein kinase inhibitor, attenuates basal forebrain-lesion-induced amnesia and cholinergic neuronal deficit," Neuroscience Letters 122:13-16 (1991).
Nabeshima et al., "Staurosporine Facilitates Recovery from the Basal Forebrain-Lesion-Induced . . . Cholinergi Neuron in Rats," The Journal of Pharmacology and Experimental Therapeutics 257:562-566 (1991).
Nakadate et al., "Comparison of Protein Kinase C Functional Assays to Clarity Mechanism of Inhibitor Action," Biochemical Pharmacology 37:1541-1545 (1988).
Nakanishi et al., "K-252b, c and d, Potent Inhibitors of Protein Kinase C From Microbial Origin," The Journal of Antibiotics 39:1066-1071 (1986).
Ohno et al., "Effect of Staurosporine, a Protein Kinase C Inhibitor, on Impairment of Working Memory in Rats Exposed to Cerebral Ischemia," European Journal of Pharmacology 204:113-116 (1991).
Olton, D. et al., "Dementia: Animal Models of the Cognitive Impairments . . . Cholnergic System," Psychopharmacology: The Third Generation of Progress, Raven Press, NY (1987).
Oppenheim, R. et al., "Reduction of Naturally Occurring Motoneuron Death in Vivo by a Target-Derived Neurotrophic Factor," Science 240:919-921 (1988).
Oppenheim, "The Absence of Significant Postnatal Motoneuron Death in the Brachial and Lumbar Spinal Cord of the Rat," Journal of Comparative Neurology, 246:281-286 (1986).
Oppenheim, R. et al., "Cell Death of Motoneurons in the Chick Embryo Spinal Cord. VI. Reduction of Naturally Occurring Cell Death . . . Terni by Nerve Growth Factor," Journal of Comparative Neurology, 210:174-189 (1982).
Rasouly et al., "Staurosporine-Induced Neurite Outgrowth in PC12-Cells is Independent of Protein Kinase-C Inhibition," Molecular Pharmacology 42:35-43 (1991).
Sako et al., "Contrasting Actions of Staurosporine, a Protein Kinase C Inhibitor, on Human Neurophils and Primary Mouse Epidermal Cells," Cancer Research 48:4646-4650 (1988).
Shen et al., "Staurosparine-induced Morphological Differentiation of Human Neroblastoma Cells," Cell Biology International Reports 15:161-167 (1991).
Shepherd, "The Synaptic Organization of the Brain" Second Edition, pp. 308-314 (Oxford University Press, New York, 1979).
Siman et al., "Excitatory Amino Acids Acitvate Calpain I and Induce Structural Protein Breakdown in Vivo," Neuron 1:279-287 (1988).
Slack et al., "Effects or Retinioc Acid and Staurosporine on the Protein Kinase C Activity and the Morphology of Two Related Human Neuroblastoma Cell Lines" Biochemica at Biophysica Acta 1053:89-96 (1990).
Smith, G., "Animal models of Alzheimer's disease: experimental cholinergic denervation," Brain Research Reviews 13:103-118 (1988).
Smith et al., "Effects of a Protein Kinase C Inhibitor, K-252a, on Human Polymorphonuclear Neutrophil Responsiveness" Biochem. and Biophys. Research Communications 152:1497-1503 (1988).
Steglich et al., "Indole Pigments from the Fruiting Bodies of the Slime Mold Arcyria denudata," Agnew. Chem. Int. Ed. Engl. 19:459-460 (1980).
Tischler et al., "A Protein Kinase Inhibitor, Staurosporine, Mimics Nerve Growth Factor Induction of Neurotensin/Neuromedin N Gene Expression," The Journal of Biological Chemistry 266:1141-1146 (1991).
Vitullo, Press Release "Cephalon and Kyowa Hakko Co., Ltd. Announce Collaboration," Jun. 2, 1992.
Wolf et al., "The Protein Kinase Inhibitor Staurosporine, Like Phorbol Esters, Induces the Association of Protein Kinase C With Membranes," Biochem. and Biophys. Research

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Protein kinase inhibitors for treatmen of neurological disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein kinase inhibitors for treatmen of neurological disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein kinase inhibitors for treatmen of neurological disorders will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2057803

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.