Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

2006-10-17

2006-10-17

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S255060, C544S336000, C544S405000

Reexamination Certificate

active

07122550

ABSTRACT:
A compound of the general formula:or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of Formula I is also described.

REFERENCES:
patent: WO 02/060492 (2002-08-01), None
Duhé et al, “Negative Regulation of Janus Kinases” Cell Biochemistry and Biophysics, vol. 34(1), pp. 17-59 (2001).
Scapin, G. “Structural biology in drug design: selective protein kinase inhibitors” Drug Discovery Today, vol. 7(11), pp. 601-611 (Jun. 2002).
Ding et al., J. Am. Chem. Soc. (2002) 124(8):1594-1596.
International Search Report mailed on Jul. 4, 2003, for PCT patent application No. PCT/AU03/00629 filed on May 23, 2003, 3 pages.
Miyaura and Suzuki, Chem Rev. (1995) 95:2457.
Spiotto and Chung, Prostate (2000) 42:88-98.
Stille, Angew. Chem., Int. Ed. Engl., (1986) 25:508.

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