Protein kinase inhibitors

Details Protein kinase inhibitors Protein kinase inhibitors

2005-09-27

2005-09-27

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S149000, C546S148000, C546S146000, C546S139000

Reexamination Certificate

active

06949565

ABSTRACT:
Novel isoquinoline derivatives which are useful as inhibitors of protein kinases for experimental, medical, and drug design purposes are disclosed. Preferred compounds which are specific inhibitors of protein kinase B are also disclosed. Furthermore, pharmaceutical compositions comprising these protein kinase inhibitors, and methods of using such compositions for treatment and diagnosis of cancers, diabetes, cardiovascular pathologies, hemorrhagic shock, obesity, inflammatory diseases, diseases of the central nervous system, and autoimmune diseases, are also disclosed.

REFERENCES:
patent: 5245034 (1993-09-01), Hidaka et al.
patent: 02256666 (1989-12-01), None
Shigeo Nakamura et al.; J. Pharm. Pharmacol. 1993, 45:268-273; Effects of Isoquinolinesulphonamide Compounds on Multidrug-resistant P388 Cells.
Shinya Wakusawa et al.; Molecular Pharmacology, 41:1034-1038; Overcoming of Vinblastine Resistance by Isoquinolinesulfonamide Compounds in Adriamycin-Resistant Leukemia Cells.
K.-I. Miyamoto et al.; Cancer Letters, 51:37-42; Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.
V. John et al.; Pharm Pharmacol Lett (1994), 3:190-193; The effect of cyclic AMP-dependent protein kinase inhibitors on electrical resistance in the cell culture model for the blood-brain barrier.

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