Protein kinase A reporters useful in high throughput assays

Details Protein kinase A reporters useful in high throughput assays Protein kinase A reporters useful in high throughput assays

2006-10-26

2011-12-20

Desai, Anand (Department: 1656)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

C424S052000, C536S026600, C436S546000, C436S800000

Reexamination Certificate

active

08080235

ABSTRACT:
Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds.

REFERENCES:
patent: 2005036178 (2005-04-01), None
Zhang Jin et al., “Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes”, Nature, Sep. 2005, pp. 569-573, vol. 437, No. 7058, XP002422133 (London).
Baird G S et al. “Circular permutation and receptor insertion within green fluorescent proteins”, Proceedings of the National Academy of Sciences of USA, National Academy of Science, Sep. 28, 1999 pp. 11241-11246, vol. 96, No. 20, XP002187230, Biochemistry, (Washington, DC, USA).
Allen Michael D et al. “Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters”, Biochemical and Biophysical Research Communications, Sep. 2006, pp. 716-721, vol. 348, No. 2, XP005599167, Elsevier Inc. (USA).
International Search Report of PCT/US2006/041741, completion date Dec. 27, 2007, mail date Mar. 15, 2007.
Written Opinion of of PCT/US2006/041741.

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