Protein isolated from blood, process for preparing said protein,

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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436547, 436518, 436548, 436815, 43524027, 435 7021, 424 858, C07K 1528, G01N 3353, C12N 518, A61K 3900

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050649426

ABSTRACT:
The invention relates to Tetranectin, a new protein isolated from blood. Its structure comprises four polypeptide chains having the formula shown in the attached drawing.
Tetranectin plays a role in the hemostatic system and, therefore, may be used as an agent for regulation of hemostasis.
Further, the invention relates to a process for preparing Tetranectin in which Tetranectin is isolated, e.g. from blood or blood fractions, cells or genetically engineered organisms.
Finally the invention relates to antiserum or antibodies against Tetranectin, to immunological detection and assay methods wherein said antiserum or antibodies are used as immunological reagent, and to pharmaceutical compositions containing Tetranectin or antibodies against Tetranectin.

REFERENCES:
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Clemmensen et al. (1986), "Purification and Characterization of a Novel, Oligomeric, Plasminogen Kringle 4 Binding Protein from Human Plasma:tetranectin", Eur. J. Biochem., 156:327-333.
Clemmensen et al. (1985), "Purification and Characterization of a Plasminogen Kringle 4 Binding Protein from Human Plasma", Xth International Congress on Thrombosis and Haemostasis, 54:877.
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Sottrup-Jensen et al. (1978), "The Primary Structure of Human Plasminogen: Isolation of Two Lysine-Binding Fragments and One Mini-Plasminogen (MW, 38,000), by Elastase-Catalyzed-Specific Limited Proteolysis", Progress in Chemical Fibrinolysis and Thrombosis, 3:191-209.
Thorsen et al. (1981), "Adsorption to Fibrin of Native Fragments of Known Primary Structure from Human Plasminogen", Biochim. et Biophys. Acta., 668:337-387.
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