Protein inhibiting aggregation of beta amyloid peptide

Details Protein inhibiting aggregation of beta amyloid peptide Protein inhibiting aggregation of beta amyloid peptide

2006-09-26

2006-09-26

Weber, Jon (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07112569

ABSTRACT:
The present invention relates to a novel protein inhibiting β amyloid aggregation and a strain producing the protein, more precisely, to a novel protein inhibiting β amyloid aggregation, a gene coding the protein, aStreptomycessp. strain producing the protein and a therapeutic agent for neurodegenerative disorders containing the protein as an effective ingredient. The therapeutic agent of the present invention containing the protein inhibiting β amyloid aggregation as an effective ingredient can be effectively used for the prevention and the treatment of neurodegenerative disorders like Alzheimer's disease.

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Conway et al. Current Pharmaceutical Design 9: 427-447 (2003) “Emerging Beta-Amyloid Therapies for the Treatment of Alzheimer's Disease”.
Hwang, Sung Eun et al., Isolation of Streptomyces SP. KK565 as a Producer of β-Amyloid Aggregation Inhibitor, J. Microbiol. Biotechnol. (2003), 13(5), 809-814.
Klunk, William E. et al., Quantifying Amyloid β-Peptide (Aβ) Aggregation, Analytical Biochemistry 266, 66-76 (1999).
Spungin, Anya et al., Streptomyces Griseus Aminopeptidase Is . . . , Eur. J. Biochem. 183: 471-477 (89).
Iwata, Nobuhise et al., Identification of the Major Aβ 1-42- Degrading . . . , Nature Medicine, vol. 6, No. 2, Feb. 2000.
Eckman, Elizabeth A., Degradation of Alzheimer's . . . , The Journal of Biochemistry, vol. 276, No. 27, Issue of Jul. 6, pp. 24540-24548, 2001.
Zhu, Yinwen Judy et al., Fresh and Nonfibrillar Amyloid β . . . , The EASEB Journal, vol. 14, Jun. 2000: pp. 1244-1254.

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