Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-05-24
1998-05-26
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536103, 536112, 536123, 530412, 530417, C08B 3700, C07K 116, C07K 136
Patent
active
057567174
ABSTRACT:
Disclosed are specifically designed binding, "protein imaged" sorbents which reversibly bind with high specificity and affinity a preselected macromolecule, specifically a protein. The sorbents define one or more cavities which have a binding surface complementary in shape to the molecular surface of the macromolecule and a plurality of positively and negatively charged chemical moieties spatially distributed in a mirror image and charge inverse of a subset of the ionizable groups on the molecular surface of the macromolecule. Also disclosed are methods of producing such sorbents, useful over a range of conditions, for both preparative and analytical chromatographic separations or for use in various types of analyses.
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Nadler Timothy K.
Paliwal Sandeep K.
Regnier Fred E.
Varady Laszlo
Kight John
Lee Howard C.
PerSeptive Biosystems, Inc
Purdue Research Foundation
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