Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2004-10-21
2010-11-09
Monshipouri, Maryam (Department: 1656)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S358000
Reexamination Certificate
active
07829306
ABSTRACT:
A gene encoding a production amount-potentiating factor is introduced into an animal cell to transform the cell. Alternatively, a protein production gene and the gene encoding the production amount-potentiating factor are introduced into the animal cell to transform the cell. Herein, as the production amount potentiating factor, there is used a factor having caspase activity inhibiting activity and/or protein biosynthesis activity potentiating action, for example, baculovirus P35. Further, the animal cell is cultured by a culturing method under a condition that apoptosis is not induced, so that a protein is mass-produced.
REFERENCES:
patent: 6187588 (2001-02-01), Hui et al.
patent: 01/23592 (2001-04-01), None
Lin, G. et al., Stable cell lines expressing baculovirus P35: resistance to apoptosis and nutrient stress, and increased glycoprotein secretion, In Vitro Cell Dev.Biol.Anim., 2001, vol. 37, No. 5, pp. 293-302.
Greenberg, C.S. et al., “Cleavage of blood coagulation factor XIII and fibrinogen by thrombin during in vitro clotting,” J. Clin. Invest., 1985, vol. 75, No. 5, pp. 1463-1470.
Roy, S.N. et al., “Assembly and secretion of recombinant human fibrinogen,” J. Biol. Chem., 1991, vol. 266, No. 8, pp. 4758 to 4763.
Morita, T. et al., “Purification and properties of prothrombin activator from the venom ofEchis carinatus,” J. Biochem. 1978, vol. 83., No. 2, pp. 559 to 570.
Imamura Takayuki
Kamachi Yasuharu
Maeda Hiroaki
Matsuyama Reiko
Shirahama Hitomi
Browdy and Neimark PLLC
Juridical Foundation the Chemo-Sero-Therapeutic Research Institu
Monshipouri Maryam
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