Protein having ribonucleotide reductase activity and DNA...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C435S070100, C435S071100, C435S189000, C435S252300, C435S252330, C435S325000

Reexamination Certificate

active

10698228

ABSTRACT:
A protein having ribonucleotide reductase activity, DNA encoding the protein, antibodies to these and the like are disclosed. The protein, DNA and antibodies are useful in the prevention, treatment and diagnosis, etc. of cancer.

REFERENCES:
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patent: WO99/06552 (1999-11-01), None
patent: WO 00/15799 (2000-03-01), None
N—Geneseq—Dec. 16, 2004 Database Accession No. AAA12411 Jul. 25, 2000 from WO200015799 Tang et al. Mar. 23, 2000 priority 60/128,660 filed Apr. 8, 1999. Alignment with Seq. Id No. 1.
N—Geneseq—Dec. 16, 2004 Database Accession No. AAA12411 Jul. 25, 2000 from WO200015799 Tang et al. Mar. 23, 2000 priority 60/128,660 filed Apr. 8, 1999. Alignment with Seq. Id No. 2.
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
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Pavloff, Nadine, et al “Sequence Analysis of the Large and Small Subunits of Human Ribonucleotide Reductase”,DNA Sequence—J. DNA Sequencing and Mapping, (1992), vol. 2, No. 4-pp. 227-234. GenBank Accession No. X59618).
Reichard, Peter, “From RNA to DNA, Why So Many Reibonucleotide Reductases?”,Science(1993) vol. 260, No. 5115, 1773-1777.
Tanaka, Hiroshi, et al., “A Ribonucleotide Reductase Gene Involved In a p53-Dependent Cell-Cycle Checkpoint for DNA Damage”,Nature, (2000), vol. 404, No. 6773, p. 42-49.
Ansorge et al, T46249 hypothetical protein DKFZp761E1312.1. Feb. 4, 2000. EMBL Acc# AL137348. Alignment with Seq. Id No. 1.
Pavloff et al, Ribonucleoside-diphosphate reductuase M2 chain. Jul. 1, 1993. SwissProt Acc# P31350. Alignment with Seq Id No. 1.
Duclert et al, Human secreted protein encoded by 5′Est Seq Id No.: 88. ID# AAY13074 from WO9906552-A2. 22=Jun. 1999. Alignment with Seq. Id No. 1.
Yumi et al, Ribonucleotide Reductase Abstract from JP10014582A. Jan. 20, 1998 and attached IDS for PCT/JP00/04189.

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