Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1986-09-04
1989-03-07
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 530848, 530324, A61K 3764
Patent
active
048107808
ABSTRACT:
Protein having a phospholipase A.sub.2 inhibitory activity which has the nature to be induced from cells upon administration of glucocorticoid and has a phospholipase A.sub.2 inhibitory activity.
REFERENCES:
patent: 4402872 (1983-09-01), Bohn
Flower et al., "Anti-Inflammatory Steroids Induce Biosynthesis of a Phospholipase A.sub.2 Inhibitor which Prevents Prostaglandin Generation" Nature, vol. 278, pp. 456-459.
Blackwell et al., "Macrocorton: A Polypeptide Causing the Anti-Phospholipase Effect of Gluco-Corticoids" Nature, vol. 287, Sep. 11, 1980, pp. 147-149.
Wallner et al., "Cloning and Expression of Human Lipocortin, a Phospholipase A.sub.2 Inhibitor with Potential Anti-Inflammatory Activity" Nature, vol. 320, Mar. 6, 1986, pp 20 and 77-81.
Rothhut et al., "Further Characterization of the Glucocorticoid-Induced Antiphospholipase Protein `Renocortin`" Biochem Biophyl Res Comm, vol. 117, No. 3, 1983, pp. 878-884.
Hirata et al., "A Phospholipase A.sub.2 Inhibitory Protein in Rabbit Neutrophils Induced by Glucocorticoids" Proc Nat'l Acad Sci, USA , vol. 77, No. 5, pp. 2533-2536, May 1980.
DiRosa et al., "Nomenclature Announcement-Anti-Phospholipase Proteins" VIth International Conference on Prostaglandins, Oct., 1984, vol. 28, No. 4, pp. 440-443.
Pepinsky et al., "Purification and Partial Sequence Analysis of a 37-kDa Protein That Inhibits Phospholipase A.sub.2 Activity From Rat Peritoneal Exudates" J. Biol. Chem., vol. 261, No. 9, Mar. 25, pp. 4239-4246, 1986.
Imaizumi Atsushi
Kamimura Takashi
Okada Masahiro
Suwa Yorimasa
Kight John
Nutter Nathan M.
Teijin Limited
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