Protein having hemolytic activity and gene encoding the protein

Details Protein having hemolytic activity and gene encoding the protein Protein having hemolytic activity and gene encoding the protein

2005-02-15

2005-02-15

Carlson, Karen Cochrane (Department: 1653)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S350000, C435S069100

Reexamination Certificate

active

06855803

ABSTRACT:
Novel proteins having hemolytic activity giving the new approach of development of the drugs, and having the following property are provided:(1) having hemolytic activity;(2) having a molecular weight of about 50,000 Da (determined by SDS gel electrophoresis); and(3) having an amino acid sequence represented by any of SEQ ID NO 1 and SEQ ID NO 2 as a partial amino acid sequence represented by the following amino acid sequences (1) and (2);Amino acid sequence (1):Tyr-Arg-Asp-Gln-Glu-Leu-Glu-Asp-Asn-Val-LysAmino acid sequence (2):Lys-Trp-Pro-Asp-Tyr-Phe-Val-Tyr-Met-Glu-Ser-Ser-Ala-His-Gly-Tyr-Ile-Arg(wherein, an amino acid residue is written by the 3 letters notation defined by IUPAC and IUB)obtained from nematocyst ofCarybdea alata.

REFERENCES:
patent: 6653449 (2003-11-01), Nagai et al.
patent: 9950294 (1999-10-01), None
Nagai H. et al. “Isolation and characterization of a novel protein toxin from the Hawaiian box jellyfish (sea wasp)Carybdea alata.”Biochem Biophys Res Commun. Aug. 28, 2000; 275(2):589-594.*
Rottini, et al. “Purification and properties of a cytolytic toxin in venom of the jellyfishCarybdea marsupialis”Toxicon, 1995, 33, 3, pp. 315-326.

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