Protein having cell growth-stimulating and macrophage chemotacti

Details Protein having cell growth-stimulating and macrophage chemotacti Protein having cell growth-stimulating and macrophage chemotacti

1994-12-29

1995-11-07

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 712, 435 713, 435842, 424115, C12P 2100, A61K 3800, A61K 3802

Patent

active

054648181

ABSTRACT:
There are described a novel protein derived from Clostridium perfringens FERM BP-4584 method of obtaining the same and use thereof as an effective ingredient for treating wounds and ulcers. The protein has a molecular weight of 420,000.+-.40,000 by a GPC, isoelectric point of 4.8, and consists of a single subunit having a molecular weight of 130,000.+-.20,000 by a SDS-polyacrylamide gel electrophoresis, and shows cell growth-stimulating activity as well as macrophage chemotactic action. The protein can be extracted and separated by conventional techniques for obtaining a protein from general microorganisms, by taking an inhibition of decomposition into consideration, since the protein is not so stable.

REFERENCES:
patent: 4604234 (1986-08-01), Fujii et al.
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"Disc Electrophoresis-II, Method and Application to Human Serum Proteins," Cell Research Laboratory and Department of Hematology, The Mount Sinai Hospital, Baruch J. Davis, pp. 404-427.
"Crystalline Soybean Trypsin Inhibitor-II. General Properties," From the Laboratories of the Rockefeller Institute for Medical Research, Princeton, N.J., Oct. 21, 1946, M. Kunitz.
"The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous System," J. Biol. Chem. vol. 233, pp. 184-188, Feb. 7, 1958, John M. Kissane et al.
"The Chemotactic Effect of Mixture of Antibody and Antigen on Polymorphonuclear Leucocytes," J. Exp. Med. vol. 115 (1962), pp. 453-466, Stephen Boyden.

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