Protein having anti-HIV activity and method for obtaining it

Details Protein having anti-HIV activity and method for obtaining it Protein having anti-HIV activity and method for obtaining it

1994-08-04

1997-07-01

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

435 704, 530350, A61K 3817, C07K 14435, C12P 2100

Patent

active

056438818

ABSTRACT:
A protein having potent anti-HIV activity is obtained by a method which comprises culturing a strain of CD4-positive T cells, such as a subclone of CEM cells designated 4084, in a tissue culture medium under conditions in which the cells are induced to produce and secrete a protein having anti-HIV activity, separating the cells from the culture medium containing the protein and then recovering the protein from the medium, wherein the molecular weight of the protein having anti-HIV activity is at least 30,000 daltons as determined by a membrane with defined pore size that retains molecules of 30,000 daltons.

REFERENCES:
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patent: 5149785 (1992-09-01), Cantor et al.
patent: 5157112 (1992-10-01), Van Snick et al.
patent: 5236829 (1993-08-01), Farber
patent: 5292636 (1994-03-01), Kung et al.
patent: 5346988 (1994-09-01), Nonoyama et al.
Lai et al., AIDS Research and Human Retroviruses, 6:205-217 (1990).
Shinazi et al., Antimicrob. Agents Chemother., 34:1061-1066 (1990).
Cooley et al., New England J. of Med., 322:1340-1345 (1990).
Harris et al., "Protein purification methods", 1989, IRL Press, pp. 9-10 and 57-60.
Harris et al., Protein purification methods, published 1989 by IRL Press (New York), pp. 126, 127, 139, 142.
Science, vol. 238, issued 18 Dec. 1987, Smith et al, "Blocking of HIV-1 Infectivity by a Soluble . . . ", pp. 1704-1707.

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