Protein formulation

Details Protein formulation Protein formulation

2008-09-15

2011-10-04

Noakes, Suzanne M. (Department: 1656)

Drug, bio-affecting and body treating compositions

Dentifrices

C514S012200

Reexamination Certificate

active

08029769

ABSTRACT:
A low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, is intended to be used as a therapeutic, as a prophylactic and/or as a cosmetic agent. The active enamel substance is incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or is cell-occlusive, so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. A new pharmaceutical and/or cosmetic formulation of an active enamel substance is provided at a lower total concentration within the formulation, wherein a spatial and/or selective regulation of release of said active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity.

REFERENCES:
patent: 4672032 (1987-06-01), Slavkin et al.
patent: 5874500 (1999-02-01), Rhee et al.
patent: 5997301 (1999-12-01), Linden
patent: 6503539 (2003-01-01), Gestrelius et al.
patent: 2003/0166833 (2003-09-01), Lutolf et al.
patent: 2003/0187232 (2003-10-01), Hubbell et al.
patent: 0337967 (1989-10-01), None
patent: 0 263 086 (1991-12-01), None
patent: 1 059 934 (2000-12-01), None
patent: 1 153 610 (2001-11-01), None
patent: 2004143165 (2004-05-01), None
patent: WO 00/06734 (2000-02-01), None
patent: WO 00/44808 (2000-08-01), None
patent: WO 00/53196 (2000-09-01), None
patent: WO 01/92584 (2001-12-01), None
patent: WO 01/97834 (2001-12-01), None
patent: WO 02/080994 (2002-10-01), None
patent: WO 03/052901 (2003-06-01), None
patent: WO 03/080144 (2003-10-01), None
Habelitz et al. “Amelogenin Induces Biomineralization at Specific pH”, Materials Research Society Symposium Proceedings, 2003, vol. 774, pp. O7.8.1-O7-8-6.
Gestrelius, et al., “Emdogain—peridontal regeneration based on biomimicry”, Clin Oral Invest, vol. 4, pp. 120-125, Springer-Verlag, 2000.
International Search Report from priority application PCT/IB2005/004134.
Besson, et al., “Synthetic Peptide Substrates for a Conductimetric Assay ofPseudomonas aeruginosaElastase”, Analytical Biochemistry, vol. 237, No. 232, pp. 216-223, Academic Press, Inc., 1996.
Coombs, et al., “Directing Sequence-specific Proteolysis to New Targets”, The Journal of Biological Chemistry, Vo. 273, No. 8, pp. 4323-4328, The American Society for Biochemistry and Molecular Biology, Inc., 1998.
Gestrelius et al. 1997; Formulation oof enamel matrix derivative for surface coating; kinetics and cell colonization. J. Clin. Periodontal (23(9 pt 2): 678-684.
Hammarström, et al., “Enamel matrix, cementum developement and regeneration”, J of Clin Periodontol, vol. 24, pp. 658-668, J. Clin Periodontol, 1997.
Hata, et al., “Binding of Lipoprotein Lipase to Heparin”, The Journal of Biological Chemistry, vol. 268, No. 12, pp. 8447-8457, 1993.
Harding et al., Matrix proteins-the innovative therapy changing the future for hard-to-heal wounds, Full report from the Satellite Symposium at WUWS meeting in Paris, Jul. 2004.
Haugen et al., “Central and Peripheral Neurite Outgrowth Differs in Preference for Heparin-Binding versus Integrin-Binding Sequences”, The Journal of Neuroscience, vol. 12, No. 6, pp. 2034-2042, Soceity for Neuroscience, 1992.
Hern, et al., “Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing”, J Biomed Mater Res, vol. 39, pp. 266-276, John Wiley & Sons, Inc., 1998.
Kallapur, et al., “The Neural Cell Adhesion Molecule (NCAM) Heparin Binding Domain Binds to Cell Surface Heparan Sulfate Proteoglycans”, Journal of Neuroscience Research, vol. 33, pp. 538-548, Wiley-Liss, Inc., 1992.
Lyngstadaas, et al., “Autocrine growth factors in human peridontal ligament cells cultured on enamel matrix derivative”, J Clin Periodontol, vol. 28, pp. 181-188, J. Clin Periodontol, 2001.
Netzel-Arnett, et al., “Sequence Specificities of Human Fibroblast and Neutrophil Collagenases”, The Journal of Biological Chemistry, vol. 266, No. 11, pp. 6747-6755, The American Society for Biochemistry and Molecular Biology, Inc., 1991.
Schense, et al., “Cross-Linking Exogenous Bifunctional Peptides into Fibrin Gels with Factor XIIIa”, Bioconjugate Chem., vol. 10, pp. 75-81, American Chemical Society, 1999.
Sierra, David H., “Fibrin Sealant Adhesive Systems: A Review of Their Chemistry, Material Properties and Clinical Applications”, Journal of Biomaterials Applications, vol. 7, pp. 309-352, Technomic Publishing Co., Inc., 1993.
Smith, et al., “Rapid Identification of Highly Active and Selective Substrates for Stromelysin and Matrilysin Using Bacteriophage Peptide Display Libraries”, The Journal of Biological Chemistry, vol. 270, No. 12, pp. 6440-6449, The American Society for Biochemistry and Molecular Biology, Inc., 1995.
Takagi, et al., “Amino Acid Sequence Studies on the α Chain of Human Fibrinogen. Location of Four Plasmin Attack Points and a Covalent Cross-Linking Site”, Biochemistry, vol. 14, No. 23, pp. 5149-5156, 1975.
Ten Cate, “Oral Histology Development, Structure and Function”, Eur J Oral Science, vol. 106, pp. 282-291,1994.
Tyler-Cross, et al., “Heparin binding domain peptides of antithrombin III: Analysis by isothermal titration calorimetry and circular dichroism spectroscopy”, Protein Science, vol. 3, pp. 620-627, The Protein Society, 1994.
Williams, et al., “Exogenous Matrix Precursors Promote Functional Nerve Regeneration Across a 15-mm Gap Within a Silicone Chamber in the Rat”, The Journal of Comparative Neurology, vol. 264, pp. 284-290, Alan R. Liss, Inc., 1987.
Zucker, et al., “Platelet Factor 4: Production, Structure, and Physiologic and Immunologic Action (43309)”, Exper Biol Med, pp. 693-702, Society for Experimental Biology and Medicine, 1991.
Japanese Patent Application No. JP2004143165A to Fukae English language translation.
Christoph H.F. Hämmerle & Ronald E. Jung, “Bone augementation by means of barrier membranes”, Periodontology 2000, vol. 33, 2003, 36-53.
Wang, K., et al., “Controlled Release of Enamel Matrix Protein from PEG-based Hydrogels”, 81st General Session of the International Ass. for Dental Research, p. 1, xp-002630576, 2003.
Hattar, S., et al., “Potential of biomimetic surfaces to promote in vitro osteoblast-like cell differentiation”, Biomaterials vol. 26, pp. 839-848, May 18, 2004.
Craemer, J., et al., “Bioengineering human tooth implants”, The IADR/AADR/CADR 83rd General Session, p. 1, xp-002630577, Mar. 2005.
Search Report of EP No. 10185085.7 dated May 3, 2011.

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