Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-08-16
1994-08-23
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435174, 4353201, 4352402, 43525421, 435 691, 530355, 530422, C12N 500, C07K 300, C12P 2106, C07H 1512
Patent
active
053407261
ABSTRACT:
A protein which inhibits collagen-stimulated platelet aggregation. The protein has a molecular weight of approximately 17,000. A method of isolating the protein from Ornithodoros moubata and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
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Gene, 56 (1987) 125-135 Elsevier, Rosenberg et al., Vectors for selective expression of cloned DNAs by T7 RNA polymerase.
The Journal of Cell Biology, vol. 99 (1984) 2048-2055, Shadle et al., Platelet-Collagen Adhesion: Evidence for Participation of Antigenically Distinct Entities.
The Journal of Cell Biology, vol. 99, (1984) 2056-2060, Shadle et al., Platelet-Collagen Adhesion: Inhibition by a Monoclonal Antibody That Binds Glycoprotein llb.
Thrombosis Research, vol. 12, No. 5, pp. 841-850, Fauvel et al., Platelet-Collagen Interaction: Adhesion of Human Blood Platelets to Purified (CB4) Peptide from Type III Collagen.
Platelet Adhesion to Collagen, vol. 94, No. 3, Legrand et al., Specific and Quantitative method for estimation of platelet adhesion to fibrillar collagen*.
Thrombosis Research 17; 285-287 (1980), Fauvel et al., Letter to the Editor in Chief.
Kanczewski et al. (Dec. 8-12, 1991) J Cell Biol 115 (3 part 2), 442 A.
Waxman et al. (1990) Science V. 248. pp. 593-596.
Connolly Thomas M.
Keller Paul M.
Waxman Lloyd H.
Hill Jr. Robert J.
Matukaitis Paul D.
Merck & Co. , Inc.
Parr Richard S.
Wang Gian P.
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